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. Author manuscript; available in PMC: 2013 Dec 2.
Published in final edited form as: J Neuroimmunol. 2004 Feb;147(0):50–55. doi: 10.1016/j.jneuroim.2003.10.043

Fig. 1.

Fig. 1

Microglia take up DNA fragments in Alzheimer brain and in vitro. (A and B) TUNEL positivity in cytoplasm (arrow), but not nucleus, in microglia, and in nuclei (asterisk), but not cytoplasm, of neurons in Alzheimer temporal lobe. (A) and (B) are from the same field at different magnifications (A, bar = 25 µm; B, bar= 10 µm). (C) Confocal microscopy demonstrates fluorescein-labeled fDNA within the cytoplasm of N9 microglia. (D) TUNEL-positive fDNA was seen in N9 microglia exposed to unlabeled fDNA, confirming microglial phagocytosis of fDNA.

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