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a) Structure of L3MBTL3 chemical probe, 1. b) Co-crystal structure of 1 (green) bound to two molecules of L3MBTL3. The amine meta to the aniline substituent (domain 2 amine) binds in the Kme binding pocket of MBT domain 2 of one L3MBTL3 molecule (magenta) and the amine ortho to the aniline substituent (domain 1 amine) binds to MBT domain 1 of a second L3MBTL3 molecule (cyan). c) Structures of other L3MBTL3 inhibitors.
