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Sketches of typical cell shapes for deoxygenated SS-RBCs observed in experiments.9 From left to right, the three sketches represent the “sickle”, “holly leaf” and “granular” shapes of SS-RBCs. The various cell morphologic states are mainly determined by the specific intracellular aligned hemoglobin polymer configurations, represented by the solid lines. The dots represent the post-homogeneous nucleus.
