Figure 4.
Darkfield reflectance images of cancer cells labeled with immunomagnetic nanocarriers. Columns correspond to cancer cells with the following expression profiles: COLO 205 (EpCAM+/HER2−/EGFR−/CK+), SK-BR-3 (EpCAM+/HER2+/EGFR−/CK+), and A-431 (EpCAM+/HER2−/EGFR+/CK+). Rows show labeling results obtained with (from top to bottom): anti-EpCAM, anti-HER2, anti-EGFR, anti-CK and no nanocarriers. The yellow-orange color in the darkfield images is associated with binding of the nanocarriers; unlabeled cells have a grey-bluish appearance.