Table 4.
Adjusted estimates of GSTM2 diplotypes on GSTM2 CpG site methylation by secondhand smoke exposure status at age 18
| |
cg03942855† |
cg06970744† |
||||||
|---|---|---|---|---|---|---|---|---|
| |
Not exposed (n = 93) |
Exposed (n = 130) |
Not exposed (n = 93) |
Exposed (n = 130) |
||||
| Diplotype* | β (%) | p-value§ | β (%) | p-value§ | β (%) | p-value§ | β (%) | p-value§ |
| TC_AC |
-2.09 |
0.31 |
-1.61 |
0.33 |
-0.53 |
0.80 |
-2.16 |
0.34 |
| TC_TC |
1.62 |
0.31 |
-1.80 |
0.03 |
2.19 |
0.42 |
-2.75 |
0.02 |
| TG_AC |
-1.92 |
0.33 |
-4.12 |
0.002 |
2.64 |
0.51 |
-3.14 |
0.07 |
| TG_TG |
-1.99 |
0.31 |
-1.99 |
0.02 |
-2.38 |
0.42 |
-3.28 |
0.01 |
| Minor diplotypes |
-3.88 |
0.33 |
2.26 |
0.50 |
-4.04 |
0.57 |
3.23 |
0.48 |
| TC_TG |
REF |
-- |
REF |
-- |
REF |
-- |
REF |
-- |
| pinteraction‡ | 0.03 | 0.01 | ||||||
* Comprised of SNPs as described in the Results section; †Models adjusted for in utero smoke exposure and personal smoking status; ‡ Global F-test p-value: significance of interaction; § After adjustment for false discovery rate (FDR).