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Proposed algorithm for the treatment of locally advanced (inoperable) male breast cancer.
Abbreviations: LABC, locally advanced breast cancer; CT, chemotherapy; HT, hormonal therapy; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2.
Note: 1HER2-positive tumors; 2ER positive and/or PR positive; Levels of evidence, there is insufficient evidence to support the use of trastuzumab or neoadjuvant CT in male breast cancer setting.
