Table 2. Compressed sensing (CS), mutual information (MI), and ensemble classifier predictions of HIV-1 Env positions constituting bnMAb epitopes for PGT 127, 128, and 130.

bnMAb	CS classifier			MI classifier		Ensemble classifier		Experiment
	nCS	position	residue	nMI		nCS	position	residue	nMI
PGT-127	18	136	Ser	2	332	2	332	4	301
		169	Lys		334		334		303
		188	Asn						332
		230	Asn						334
		290	Arg
		297	Thr
		322	Ile
		330	His
		332	Asn
		334	Asn
		334	Ser
		373	Thr
		442	Glu
		674	Asn
		792	Ala
		815	Val
		817	Ala
		843	Val
PGT-128	23	82	Arg	2	332	2	332	1	303
		133	Lys		334		334
		151	Gln
		152	Glu
		153	Gln
		229	Arg
		230	Asn
		289	Val
		297	Thr
		306	Arg
		323	Ile
		326	Ile
		332	Thr
		334	Ser
		347	Asp
		373	Thr
		442	Glu
		500	Glu
		520	Leu
		754	Pro
		792	Ala
		815	Val
		817	Thr
PGT-130	18	49	Asp	2	471	1	792	7	301
		151	Asp		792				303
		230	Asn						307
		297	Thr						309
		300	Ser						324
		360	Val						325
		373	Met						423
		395	Cys
		455	Glu
		465	Thr
		500	Glu
		520	Leu
		644	Asp
		746	Ser
		792	Ala
		792	Leu
		817	Thr
		841	Leu

The experimentally identified positions are defined as those at which alanine point mutations were observed to increase the measured IC₅₀ of the mutant by more than 30-fold relative to that of the wild type JR-CSF. Alanine scans were performed as part of the present work for PGT 143 and 145; data for PGT 121–135 were taken from Ref. [51].

Footnote: See footnote to Table 1.