Appendix 1.
Statistical significance (P-values) of parameters in models for availability of primary outcome measure
| Trial | Main effects*
|
Two-way interactions**
|
Three-way interaction**
|
Comment*** | |||||
|---|---|---|---|---|---|---|---|---|---|
| Treatment group | Gender | Race/Ethnicity | Age | G × RE | G × Age | RE × Age | G × RE × Age | ||
| CTN0001 | 0.932 | 0.617 | 0.941 | 0.128 | – | – | – | – | |
| CTN0002 | 0.055 | 0.668 | 0.063 | 0.009 | – | – | – | – | 35–44 > 25–34 > 45–54 > 18–24 > 55–64 |
| CTN0003 | 0.001 | 0.072 | 0.320 | 0.690 | – | – | – | – | |
| CTN0004 | 0.937 | 0.996 | 0.142 | 0.307 | – | – | – | – | |
| CTN0005 | 0.506 | 0.898 | 0.761 | 0.421 | – | – | – | – | |
| CTN0006 | 0.002 | 0.787 | 0.753 | 0.250 | – | – | – | – | |
| CTN0007 | 0.791 | 0.171 | 0.320 | 0.022 | – | – | – | – | |
| CTN0009 | 0.023 | 0.352 | 0.710 | 0.203 | – | – | – | – | |
| CTN0010 | 0.032 | 0.376 | 0.299 | 0.857 | – | – | – | – | |
| CTN0011 | 0.476 | 0.646 | 0.909 | 0.009 | – | – | – | – | 45–54 > 35–44 > 18–24 > 25–34 |
| CTN0013 | – | na | – | – | na | na | – | na | |
| CTN0014 | 0.237 | 0.780 | 0.076 | 0.312 | – | – | – | – | |
| CTN0015 | 0.979 | na | 0.120 | 0.143 | na | na | – | na | |
| CTN0017 | 0.612 | 0.154 | 0.440 | 0.002 | – | – | – | – | 55–64 > 45–54 > 18–24 > 25–34 > 35–44 |
| CTN0018 | 0.480 | na | <0.00l | <0.00l | na | na | – | na | MR > H > W > AA, 55–64 > 45–54 > 35–44 > 25–34 > 18–24 |
| CTN0019 | 0.043 | na | 0.181 | 0.061 | na | na | – | na | |
| CTN0020 | 0.356 | 0.002 | 0.037 | 0.010 | – | – | – | – | F > M, 55–64 > 45–54 > 35–44 > 25–34 > 18–24 |
| CTN0021 | 0.191 | 0.465 | na | 0.013 | na | – | na | na | |
| CTN0027 | <0.00l | 0.392 | 0.360 | <0.00l | – | – | – | – | 55–64 > 45–54 > 35–44 > 25–34 > 18–24 |
| CTN0028 | not av | 0.090 | 0.033 | 0.130 | – | – | – | – | |
| CTN0029 | not av | 0.768 | – | 0.038 | – | – | – | – | |
| CTN0030 | 0.701 | 0.555 | 0.475 | 0.217 | – | – | – | – | |
| CTN0031 | 0.066 | 0.107 | 0.429 | 0.123 | – | – | – | – | |
| CTN0032 | 0.696 | <0.00l | 0.499 | 0.015 | – | – | – | – | F > M |
Abbreviations: G, gender; RE, race/ethnicity; M, male; F, female; H, Hispanic; W, white; AA, non-Hispanic African American; MR, multirace; na, not applicable; not av, not available.
Notes:
A dash (–) indicates that the main effect could not be estimated because there was only one group left after cells with small sample size were excluded.
A dash (–) indicates that the interaction term was not statistically significant (P-value > 0.010) or could not be estimated, and was subsequently dropped from the statistical model.
For statistically significant differences in retention for specific main effects (P ≤ 0.01), the ordering of main effect categories are presented in the likelihood of retention to the study visit corresponding to the primary outcome assessment, from highest retention to lowest retention.