Appendix 3.
Trial | Main effects*
|
Two-way interactions**
|
Three-way interaction**
|
Comment*** | |||||
---|---|---|---|---|---|---|---|---|---|
Treatment group | Gender | Race/Ethnicity | Age | G × RE | G × Age | RE × Age | G × RE × Age | ||
CTN0001 | 0.693 | 0.504 | 0.012 | 0.834 | – | – | – | – | |
CTN0002 | 0.002 | 0.660 | 0.007 | 0.025 | – | – | – | – | AA > VV > H |
CTN0003 | 0.044 | 0.044 | 0.055 | 0.221 | – | – | – | – | |
CTN0004 | 0.415 | 0.925 | 0.086 | 0.994 | – | – | – | – | |
CTN0005 | 0.608 | 0.423 | 0.848 | 0.360 | – | – | – | – | |
CTN0006 | 0.193 | 0.046 | 0.142 | 0.449 | – | – | – | – | |
CTN0007 | 0.729 | 0.032 | 0.047 | 0.035 | – | – | – | – | |
CTN0009 | 0.136 | 0.309 | 0.111 | 0.053 | – | – | – | – | |
CTN0010 | 0.217 | 0.520 | 0.513 | 0.436 | – | – | – | – | |
CTN0011 | 0.762 | 0.797 | 0.328 | 0.011 | – | – | – | – | |
CTN0013 | 0.880 | na | 0.602 | 0.191 | na | na | – | na | |
CTN0014 | 0.674 | 0.475 | 0.001 | – | – | – | – | – | H > VV > MR > AA |
CTN0015 | 0.965 | na | 0.117 | 0.148 | na | na | – | na | |
CTN0017 | 0.946 | 0.080 | 0.406 | 0.007 | – | – | – | – | 55–64 > 45–54 > 25–34 > 18–24 > 35–44 |
CTN0018 | 0.589 | na | <0.00l | <0.00l | na | na | – | na | MR > H > W > AA, 55–64 > 45–54 > 25–34 > 35–44 > 18–24 |
CTN0019 | 0.025 | na | 0.391 | 0.060 | na | na | – | na | |
CTN0020 | 0.574 | 0.011 | 0.138 | 0.033 | – | – | – | – | |
CTN0021 | 0.098 | 0.480 | na | 0.020 | na | – | na | na | |
CTN0027 | <0.00l | 0.881 | 0.532 | <0.001 | – | – | – | – | 55–64 > 45–54 > 35–44 > 18–24 > 25–34 |
CTN0028 | not av | 0.083 | 0.072 | 0.751 | – | – | – | – | |
CTN0029 | not av | 0.705 | – | 0.028 | – | – | – | – | |
CTN0030 | na | na | na | na | na | na | na | na | |
CTN0031 | 0.049 | 0.255 | 0.510 | 0.656 | – | – | – | – | |
CTN0032 | 0.459 | <0.00l | 0.832 | 0.651 | – | – | – | – | F > M |
Abbreviations: G, gender; RE, race-ethnicity; M, Male; F, Female; H, Hispanic; W, White; AA, Non-Hispanic African American; MR, Multi-Race; AI, Non-Hispanic American Indian/Alaska Native; na, not applicable; not av, not available.
Notes:
A dash (–) indicates that the main effect could not be estimated because there was only one group left after cells with small sample size were excluded.
A dash (–) indicates that the interaction term was not statistically significant (P-value > 0.010) or could not be estimated, and was subsequently dropped from the statistical model.
For statistically significant differences in retention for specific main effects (P ≤ 0.01), the ordering of main effect categories are presented in the likelihood of retention to the study visit corresponding to the primary outcome assessment, from highest retention to lowest retention.