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. 2013 Sep 9;13:190. doi: 10.1186/1471-2148-13-190

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Copyright © 2013 Alves et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Overview of the biosynthetic pathways of essential amino acids in trypanosomatids. Dashed arrows: metabolite import; dotted arrows: reaction present in only some of the organisms analyzed; solid arrows: other reactions (a single arrow can summarize multiple steps); arrows surrounded by a gray box: enzymes possibly acquired through horizontal transfer from Bacteria to trypanosomatids (see main text). A. Contribution of symbiont-harboring trypanosomatids (SHT) and endosymbionts (TPE) based on the analysis of gene content in the genomes of A. deanei, A. desouzai, S. culicis, S. oncopelti, S. galati, and respective endosymbionts. B. Biochemical capability of trypanosomatids without symbionts (RT), based on the analysis of genomic data from H. muscarum, C. acanthocephali, and L. major.