Serum free testosterone, fasting insulin levels and insulin sensitivity (HOMA IS), in women with PCOS having normal insulin levels, before and after the administration of insulin-sensitizing drugs or placebo for 6 months. (a) Testosterone concentrations and (b) fasting insulin levels and HOMA IS are shown as data represented by mean and 95% confidence interval. *P < 0.05 for comparison with the group given placebo and †P < 0.05 for comparison with the group given rosiglitazone, using Tukey HSD tests after ANCOVA analysis, adapted from Baillargeon et al. [47], with permission.