Table 1A.

Ongoing clinical trials of lapatinib in the metastatic setting: lapatinib plus chemotherapy

Study	Status	Patient population	Study design and treatment regimen	Phase	N
NCT00496366	Ongoing	First-line for HER2+, stage III/IV	Single-arm, open-label, capecitabine + lapatinib	II	11
NCT00721630	Ongoing	HER2+ MBC	Single-arm, open-label, capecitabine + lapatinib	II	24
NCT00903656	Ongoing	HER2+, advanced or MBC	Single-arm, open-label, doxorubicin + lapatinib	II	30
NCT00508274	Ongoing	HER2+, stage III/IV	Open label, capecitabine + lapatinib	III	52
NCT00820222	Ongoing	HER2+ MBC	Randomized, capecitabine + lapatinib or trastuzumab	III	650
NCT00667251	Ongoing	HER2+ MBC	Randomized, docetaxel or paclitaxel with lapatinib vs trastuzumab	III	600
NCT00281658	Ongoing	HER2+ MBC	Randomized, double-blind, paclitaxel ± lapatinib	III	444
NCT00709618	Ongoing	First-/second-line HER2+ MBC	Single-arm, open-label, vinorelbine + lapatinib	II	60
NCT00709761	Ongoing	First-/second-line HER2+ MBC	Single-arm, open-label, nab-paclitaxel + lapatinib	II	60
NCT00272987	Ongoing	HER2+ MBC	Open-label, paclitaxel + trastuzumab + lapatinib	III	63
NCT01128543	Ongoing	HER2+ MBC	Single-arm, open-label, vinorelbine + lapatinib	II	29
NCT00829166	Ongoing	Trastuzumab refractory, HER2+	Randomized, open-label, trastuzumab emtansine vs capecitabine + lapatinib	III	980
NCT01013740	Ongoing	First-/second-line HER2+ MBC	Randomized, open-label, vinorelbine + lapatinib vs capecitabine + lapatinib	II	105

Abbreviations: HER2+, HER2 positive; MBC, metastatic breast cancer; vs, versus.