Table 4.

Ongoing clinical trials of lapatinib in patients with central nervous system (CNS) metastases

Study	Status	Patient population	Study design and treatment regimen	Phase	N
NCT00263588	Ongoing	HER2+ with CNS metastases after trastuzumab-based regimen and WBRT	Single-arm, open-label, lapatinib	II	242
NCT00470847	Ongoing	HER2+ with CNS metastases	Single-arm, open-label, WBRT + lapatinib	II	39
NCT00614978	Ongoing	HER2+ with CNS relapse	Single-arm, open-label, temozolomide + lapatinib	I	18
NCT00967031	Ongoing	HER2+ with CNS metastases	Single-arm, open-label, capecitabine + lapatinib	II	45
NCT01218529	Ongoing	Lung or breast cancer with CNS metastases	Single-arm, open-label, WBRT + lapatinib	II	81

Abbreviations: HER2+, human epidermal growth factor receptor 2 positive; WBRT, whole-brain radiotherapy.