Table 4.

Significant canonical pathways associated with seminal plasma

Ingenuity Canonical Pathways	Ratio	Proteins
Eumelanin Biosynthesis	5E-01	MIF
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis	1.35E-02	MIF, FN1
Intrinsic Prothrombin Activation Pathway	8.33E-02	KLK3
MSP-RON Signaling Pathway	5.88E-02	KLK3
MIF-mediated Glucocorticoid Regulation	4.76E-02	MIF
MIF Regulation of Innate Immunity	4E-02	MIF
Thyroid Cancer Signaling	3.57E-02	KLK3
Neurotrophin/TRK Signaling	2.5E-02	KLK3
Atherosclerosis Signaling	1.89E-02	CLU
Prostate Cancer Signaling	1.79E-02	KLK3
LXR/RXR Activation	1.56E-02	CLU
Human Embryonic Stem Cell Pluripotency	1.56E-02	KLK3
IL-12 Signaling and Production in Macrophages	1.54E-02	CLU
Hepatic Fibrosis / Hepatic Stellate Cell Activation	1.2E-02	FN1
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages	1.11E-02	CLU
Acute Phase Response Signaling	1.06E-02	FN1
Clathrin-mediated Endocytosis Signaling	1.06E-02	CLU
ILK Signaling	1.05E-02	FN1
Actin Cytoskeleton Signaling	9.01E-03	FN1

Pathways associated with proteins specific to ROS- group are in bold. MSP-RON Macrophage-stimulating protein- transmembrane receptor kinase, MIF Macrophage migration inhibitory factor, TRK Tyrosine kinase, LXR/RXR Liver X receptor / retinoid X receptor, IL Interleukin, KLK3 Prostate specific antigen, CLU Clusterin, FN1 Fibronectin 1 isoform 3 preprotein.