Table 5.

Significant pathways, networks and processes identified from Metacore analysis of seminal plasma proteins

Metacore pathways	Proteins (from our dataset) associated with the category
Protein folding and maturation	KLK3
Immune response	CLU
Androgen receptor signaling	KLK3
Extracellular matrix remodeling (ECM)	KLK3
ATP/ Ionisitol triphosphate metabolism	ACPP
Metacore process networks
Reproduction	KLK3, CLU
Proteolysis ECM remodeling	KLK3, CLU
Proteolysis connective tissue degradation	KLK3
Inflammation	CLU
Signal transduction	PIP, KLK3
Reproduction feeding and neurohormone signaling	PIP
Immune response antigen presentation	AZGP1
Regulation of angiogenesis	CLU
Metabolic network
Alpha-L-fucosyl (1–2)-D-galactose pathway	KLK3, SEMG1, SEMG2
Phosphatidylethanolamine pathway	KLK3
2-arachidonoyl-glycerol 3-phosphocholine pathway	KLK3
Lipid metabolism phospholipid metabolism	ACPP
Biological processes
Insemination	SEMG1, KLK3
Liquefaction of seminal ejaculate	KLK3
Reproduction	KLK3, CLU, SEMG1, SEMG2

KLK3 Prostate specific antigen, CLU Clusterin, ACPP Prostatic acid phosphatase / prostatic specific acid phosphatase, PIP Prolactin-inducing protein, AZGP1 Zinc-alpha-2-glycoprotein, SEMG1 Semenogelin-I, SEMG2 Semenogelin-II.