Table 2.

Drugs used to treat primary biliary cirrhosis

Drug	Efficacy	Toxicity
Glucocorticoids56,57,101–104	Limited efficacy	Worsen osteoporosis
Azathioprine58–60,102	Limited efficacy	+/−
Cyclosporine61,62	Limited efficacy	Many side effects
Methotrexate63–65,107–110	Efficacy not proven in double-blind trials	+
D-penicillamine66	No efficacy	Serious toxic effects
Colchicine67,68,105,106	Efficacy not proven in double-blind trials	−
Mycophenolate mofetil111,112	Limited efficacy
Silymarin113	No efficacy in pilot study