Table 4.

Treatment of the symptoms of primary biliary cirrhosis

Pruritus
1st line	Cholestyramine 4 g/day (before and after breakfast)
2nd line	Rifampin 150 mg twice daily
3rd line	Sertraline (antidepressant)
4th line	Naloxone/naltrexone by an experienced physician
5th line	Liver transplantation
Supportive	Ultraviolet light, sunlight
Emergency	Plasmapheresis
Raynaud’s
1st line	Calcium channel blockers
2nd line	Alternative: prostacyclin and its derivatives, endothelin receptor antagonists, and phosphodiesterase inhibitors
Sicca syndrome
Dry eyes	Artificial tears
Dry mouth	Dental hygiene, dental visit every 3–6 months
Dry vagina	Vaginal lubricants

Reproduced with permission from Kumagi T, Heathcote EJ. Primary biliary cirrhosis. Orphanet J Rare Dis. 2008;3:1.1