Table 2.
Maximum and week 12 acute GU and GI toxicity
| Group | |
Max GU toxicity |
|
|
|
Max GI toxicity |
|
||
|---|---|---|---|---|---|---|---|---|---|
| Grade | 0 | 1 | 2 | 3 | 0 | 1 | 2 | 3 | |
| Arm 1 |
|
10 (18%) |
31 (54%) |
12 (21%) |
4 (7%) |
16 (28%) |
18 (32%) |
23 (40%) |
0 (0%) |
| Arm 2 |
|
8 (12%) |
43 (64%) |
11 (16%) |
5 (7%) |
17 (25%) |
24 (36%) |
26 (39%) |
0 (0%) |
| Fisher’s test p |
NS |
NS |
NS |
NS |
NS |
NS |
NS |
- |
|
| |
|
GU toxicity at week 12 |
|
|
|
GI toxicity at week 12 |
|
||
| Arm 1 |
|
28 (55%) |
21 (41%) |
2 (4%) |
0 (0%) |
36 (71%) |
8 (16%) |
7 (13%) |
0 (0%) |
| Arm 2 |
|
46 (85%) |
7 (13%) |
1 (2%) |
0 (0%) |
48 (89%) |
4 (7%) |
2 (4%) |
0 (0%) |
| Fisher’s test p | 0.001 | 0.002 | NS | - | 0.027 | NS | NS | - | |
Abbreviations: Arm 1 = conventional fractionation; Arm 2 = hypofractionation; NS = difference not significant (p < 0.05).