Figure 1. IL-1β treatments reduce intestinal colonization and dissemination of C. rodentium in Nlrp3^−/− mice.

Infected mice were given repeated IL-1β treatments on 0, 2, and 4 DPI. C. rodentium colonization of the (A) cecum, (B) colon, and (C) dissemination to MLN were assessed on 6 and 10 DPI by plating homogenates on MacConkey agar plates in serial dilutions. IL-1β treatments of Nlrp3^−/− mice significantly lowered cecum colonization on 6 DPI, and colon colonization and dissemination to MLN on 10 DPI. Values were Log₁₀ transformed and data presented as mean ± SE. One asterisk: P<0.05, two asterisks: P<0.01.