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. 2013 Aug 28;14:583. doi: 10.1186/1471-2164-14-583

Figure 4.

Figure 4

Time-Series Gene Ontology (GO) Enrichment Analysis of Deregulated Transcripts after SCI. A. Number of enriched GO terms as a function of fold change and p-value of enrichment parameters. Filtering criteria in STEM were set to different values between 1 and 4, and the number of Biological Process GO terms with corrected p-values of ≤ 0.001, ≤0.0001 and ≤ 0.00001 were calculated and plotted. B. Distribution of enriched GO terms with to GO levels 3–20. GO enrichment analysis was performed on transcripts with a minimum of 1.5 fold changes in expression (ANOVA t test p ≤ 0.05). This resulted in 329 and 649 enriched GO terms at p-value cutoffs of 0.0001 and 0.001, respectively. Enriched Biological Process GO categories were positioned on the directed acyclic graph (DAG) structure of the gene ontology hierarchy. The number of significant GO terms at every GO level at were plotted and also shown on top of each bar. Note that at p ≤ 0.001, no GO terms were obtained at GO levels 15–17.