Table 1.
Univariate logistic regression model used to predict severe-complicated C. difficile infection in hospitalized patients (n=1446).
| Variable | Odds Ratio | 95% Confidence Interval | p-value |
|---|---|---|---|
| Female gender | 0.9 | 0.7–1.1 | 0.4 |
|
| |||
| Age per 10 years1 | 1.1 | 1.0–1.2 | <0.0001 |
|
| |||
| Weighted Charlson Comorbidity index2 | |||
|
| |||
| =0 | 1.0(reference) | 0.0008 | |
| =1 | 5.7 | 1.8–17.6 | 0.0023 |
| >1 | 6.0 | 2.3–15.4 | 0.0002 |
|
| |||
| Peripheral WBC count 3 | 2.7 | 2.1–3.4 | <0.0001 |
|
| |||
| Serum creatinine increase 4 | 2.1 | 1.6–2.6 | <0.0001 |
|
| |||
| Serum albumin5 | 0.6 | 0.4–0.8 | <0.0001 |
|
| |||
| Fever6 | 1.6 | 1.1–2.3 | 0.01 |
|
| |||
| Serum lactate7 | 1.5 | 1.3–1.7 | <0.0001 |
|
| |||
| Narcotic use8 | 2.5 | 1.9–3.2 | <0.0001 |
|
| |||
| H2 blockers or PPI use8 | 2.7 | 2.0–3.6 | <0.0001 |
|
| |||
| Antimotility use8 | 1.0 | 0.7–1.5 | 0.79 |
1
Age was treated as a continuous variable and studied in 10 year intervals
2
Limited to Olmsted County, MN patients (n=535)
3
Peripheral white blood cell (WBC) count was dichotomized as ≥15 × 109/L or <15 × 109/L
4
Increase in serum creatinine was dichotomized as ≥1.5 fold or <1.5 fold compared to baseline
5
Serum albumin was treated as a continuous variable
6
Temperature was dichotomized as ≥38.3 degrees Celsius or <38.3 degrees
7
Serum lactate was treated as a continuous variable
8
Medication use was examined 7 days prior to and 30 days after C. difficile infection diagnosis