Table 2.

Univariate analysis of antibiotic use as a predictor of severe-complicated C. difficile infection (CDI) in hospitalized patients (n=1446). Antibiotic use was divided into two time periods: 90 days prior to CDI diagnosis and 30 days after CDI diagnosis.

Time period of antibiotic use	Odds Ratio	95% Confidence Interval	p-value
30 days after CDI diagnosis	2.5	1.6–3.8	<0.001
90 days prior to CDI diagnosis	1.7	1.2–2.5	0.007
90 days prior to and 30 days after CDI diagnosis	2.4	1.7–3.4	<0.001
No antibiotic use	1.0	Reference