Figure 6. Biophysical modeling of the relationship between average liposome concentration (relative to plasma), the intra-tumoral distribution of liposomes, and tumor IFP.

As α increases (which is equivalent to an increase in IFP) the ITTM model predicts a decrease in the average concentration of liposomes in the tumor volume (a) and the transitions from uniform to periphery-dominated, non-uniform intra-tumoral liposome accumulation (b).