Table 1. Effects of BK preconditioning on physiological parameters, cardiac function and infarct size at 10 days following myocardial infarction.
| Variable | Baseline | Sham | Con | EPCs | BK PC | BK PC/HOE | BK PC/LY | BK PC/LN |
|---|---|---|---|---|---|---|---|---|
| HW/BW (mg/g) | 5.54±0.76 | 5.93±0.54 | 7.94±0.33 | 7.14±0.41* | 6.63±0.39 *# | 7.15±0.46 | 7.17±0.35 | 7.18±0.52 |
| LVEF(%) | 83.76±1.32 | 81.51±0.82 | 28.02±2.10 | 35.08±2.76* | 44.85±4.17*# | 34.63±1.53 | 34.15±1.63 | 35.19±3.16 |
| LVFS(%) | 52.18±1.24 | 49.09±0.13 | 12.85±0.95 | 16.41±1.54* | 26.60±2.62*# | 16.73±0.71 | 16.31±0.70 | 16.97±1.15 |
| LVIDd (mm) | 3.03±0.21 | 3.21±0.09 | 5.08±0.23 | 4.40±0.27* | 3.54±0.32*# | 4.48±0.22 | 4.59±0.21 | 4.51±0.32 |
| LVIDs (mm) | 1.52±0.09 | 1.63±0.06 | 4.42±0.17 | 3.68±0.26* | 2.60±0.25*# | 3.73±0.22 | 3.80±0.21 | 3.67±0.51 |
| Infarct size (%) | 0 | 0 | 42.55±1.93 | 35.27±3.23* | 27.28±2.75*# | 35.76±4.52 | 35.04±5.25 | 35.06±4.97 |
Values are expressed as mean ± SEM. MI mice were randomized to one of six experimental groups.
HW, heart weight; BW, body weight. LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening; LVIDd, left ventricular internal diameter at end-diastole; LVIDs, left ventricular internal diameter at end-systole. Baseline, at the beginning of the normal model construction prior to the operation in the studied mice; BK, bradykinin; PC, preconditioning; HOE, HOE140; LY, LY294002; LN, L-NAME. * P < 0.01 vs. Baseline, Sham, and Con group, # P < 0.01 vs. EPCs group. n = 5 - 6 for each group.