Skip to main content
. 2013 Dec 2;8(12):e81505. doi: 10.1371/journal.pone.0081505

Table 1. Effects of BK preconditioning on physiological parameters, cardiac function and infarct size at 10 days following myocardial infarction.

Variable Baseline Sham Con EPCs BK PC BK PC/HOE BK PC/LY BK PC/LN
HW/BW (mg/g) 5.54±0.76 5.93±0.54 7.94±0.33 7.14±0.41* 6.63±0.39 *# 7.15±0.46 7.17±0.35 7.18±0.52
LVEF(%) 83.76±1.32 81.51±0.82 28.02±2.10 35.08±2.76* 44.85±4.17*# 34.63±1.53 34.15±1.63 35.19±3.16
LVFS(%) 52.18±1.24 49.09±0.13 12.85±0.95 16.41±1.54* 26.60±2.62*# 16.73±0.71 16.31±0.70 16.97±1.15
LVIDd (mm) 3.03±0.21 3.21±0.09 5.08±0.23 4.40±0.27* 3.54±0.32*# 4.48±0.22 4.59±0.21 4.51±0.32
LVIDs (mm) 1.52±0.09 1.63±0.06 4.42±0.17 3.68±0.26* 2.60±0.25*# 3.73±0.22 3.80±0.21 3.67±0.51
Infarct size (%) 0 0 42.55±1.93 35.27±3.23* 27.28±2.75*# 35.76±4.52 35.04±5.25 35.06±4.97

Values are expressed as mean ± SEM. MI mice were randomized to one of six experimental groups.

HW, heart weight; BW, body weight. LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening; LVIDd, left ventricular internal diameter at end-diastole; LVIDs, left ventricular internal diameter at end-systole. Baseline, at the beginning of the normal model construction prior to the operation in the studied mice; BK, bradykinin; PC, preconditioning; HOE, HOE140; LY, LY294002; LN, L-NAME. * P < 0.01 vs. Baseline, Sham, and Con group, # P < 0.01 vs. EPCs group. n = 5 - 6 for each group.