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. 2004 Mar 15;101(12):4024–4029. doi: 10.1073/pnas.0306980101

Table 2. Imidazole inhibition of JH III production by CA in vitro and by recombinant CYP15A1.

Imidazole IC50 CA in vitro, μM* IC50 CYP15A1, μM†
TH27 graphic file with name zpq011044224t2s1.jpg
0.036 0.025 ± 0.014
KK96 0.77 0.2 ± 0.09
KK71 48 60 ± 5
*

Concentration for 50% inhibition of JH III biosynthesis by CA in vitro. The IC50 values were taken from ref. 12 (KK96 and TH27) and ref. 20 (KK71).

†

Concentration for 50% inhibition of methyl (2E,6E)-farnesoate epoxidation by recombinant CYP15A1 in a reconstituted system (mean ± SD, n = 3). Epoxidation of methyl farnesoate by E. coli membranes containing recombinant CYP15A1 was measured as described in Materials and Methods.