Table 2.
Incidence rate and hazard ratios for chronic kidney disease (CKD) in the hepatitis C virus (HCV)-infected and HCV-uninfected control groups during the 6-year follow-up period (n = 15910)
|
Control group |
HCV-infected group |
p | |
|---|---|---|---|
| (n = 12728) N (%) | (n = 3182) N (%) | ||
| No. of CKD |
187 (1.5) |
64 (2.0) |
0.028 |
| Mean follow-up (y) |
5.92 |
5.88 |
0.0004 |
| Total follow-up (person-year) |
75371 |
18697 |
|
| Incidence ratea |
2.48 |
3.42 |
0.02 |
| Mean time to CKD (y) |
3.13 |
2.36 |
0.003 |
| Crude HR (95% CI) |
1.00 (reference) |
1.38 (1.04-1.83) |
0.026 |
| Adjusted HR (95% CI)b | 1.00 (reference) | 1.75 (1.25-2.43)† | 0.0009 |
Abbreviations: CI confidence interval, HR hazard ratio.
aPer 1000 person-years.
bAdjusted for age, gender, diabetes, hypertension, coronary heart disease, hyperlipidemia, liver cirrhosis, geographic region, urbanization level, enrolee category, and number of healthcare visits in 1 year before study entry.
†Note: Adjusted HR with 95% CI of CKD in association with HCV was 1.97 (1.43-2.73, p < 0.0001) if the number of healthcare visits was not included in multivariate analysis.