Table 1.

Factors affecting progression to hepatocellular carcinoma in hepatitis C-related compensated cirrhosis

Host-related
Age at diagnosis	Relevant
Age at infection	Relevant
Male gender	Relevant
Severity of liver disease at presentation	Relevant
Comorbidity
Porphyria cutanea tarda	Important (Southern Europe and the US)
Iron overload	Controversial
Liver steatosis	Growing evidence
Diabetes mellitus	Growing evidence
Virus-related
Viral genotype	Controversial
Viral burden	Insufficient evidence
Overt HBV coinfection	Relevant
Occult HBV infection	Growing evidence
HIV coinfection	Growing evidence
External
Alcohol intake	Relevant
Smoking	Controversial

Abbreviations: HBV, hepatitis B virus; HCV, hepatitis C virus; HIV, human immunodeficiency virus.