Fig. 6.

BAL redistributes arsenic to the brain of rabbits. Rabbits were injected with 25 μmol/kg sc radiolabeled sodium arsenite (74As), followed in 1 h by saline (control) or various antidotes (0.2 mmol/kg i.m.) (n = 3 per treatment group). At 24 h, the animals were sacrificed and the amount of 74As in the brain as a percent of administered dose was measured. Note that BAL more than doubled the arsenic content of the brain. DMPS yielded a substantial decrease in brain arsenic. (Aposhian [10]) [Reproduced from Fundamental and Applied Toxicology with permission from Elsevier.]