Fig. 7.

BAL redistributes mercuric ion to brain of mice. Autoradiograms of sagittal whole-body sections of mice 8 days after injection of phenylmercuric acetate (²⁰³Hg) (0.5 mg Hg/kg iv via tail vein) (upper panel) and phenylmercuric acetate (²⁰³Hg) (0.5 mg Hg/kg iv) plus simultaneous BAL 0.4 mg/kg (lower panel). The isotope reference scales accompanying the sections are shown; the activity ratio between adjacent steps is ½ (darker corresponds to more ²⁰³Hg). The upper panel is from a pregnant mouse. Note the prominent redistribution of ²⁰³Hg in the brain of the mouse administered BAL simultaneous with the phenylmercuric acetate. (Berlin [23]) [Reproduced from the Journal of Pharmacology and Experimental Therapeutics with permission from the American Society for Pharmacology and Experimental Therapeutics.]