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. 2013 Nov 1;9(4):380–404. doi: 10.1007/s13181-013-0352-5

Table 13.

Opioid analgesic agents

Agents 2010 (%) 2011 (%) 2012 (%) Total (%)
Opiates Morphine 37 (5) 56 (5) 69 (6) 162 (6)
Codeine 23 (3) 12 (1) 22 (3) 57 (2)
Opium tincture 0 (0) 1 (0) 1 (0) 2 (0)
Semisynthetic opioids Oxycodone 142 (23) 252 (23) 238 (22) 632 (22)
Hydrocodone 110 (18) 160 (15) 136 (13) 406 (14)
Heroin 61 (10) 134 (12) 137 (13) 332 (12)
Buprenorphine 20 (3) 49 (4) 50 (5) 119 (4)
Hydromorphone 14 (2) 24 (2) 23 (2) 61 (2)
Oxymorphone 2 (0) 11 (1) 10 (1) 23 (1)
Synthetic opioids Methadone 98 (16) 155 (14) 147 (14) 400 (14)
Tramadol 49 (8) 98 (9) 104 (10) 251 (9)
Fentanyl 36 (6) 50 (5) 46 (4) 132 (5)
Propoxyphene 19 (3) 12 (1) 7 (1) 38 (1)
Meperidine 2 (0) 3 (0) 3 (0) 8 (0)
Loperamide 0 (0) 1 (0) 2 (0) 3 (0)
Sufentanil 0 (0) 1 (0) 1 (0) 2 (0)
Tapentadol 1 (0) 1 (0) 7 (1) 9 (0)
Diphenoxylate 1 (0) 0 (0) 0 (0) 1 (0)
Pentazocine 1 (0) 0 (0) 1 (0) 2 (0)
Unspecified opiates 19 (0) 34 (2) 66 (6) 119 (4)
Opioid antagonistsa Naloxone 9 (1) 42 (4) 14 (1) 65 (2)
Naltrexone 0 (0) 4 (0) 2 (0) 6 (0)
Totals 644 1,100 1,086 2,830

aOpioid antagonist when not in use specifically as an antidote (i.e., when used as part of an addiction therapy program such as naltrexone for alcohol or opioid addiction, or when an adverse event occurs during the use of diverted or injected Suboxone™)