Table 2.
Summary of the specific functional domains affected by each of the two lead exposure regimens and the efficacy of succimer chelation in alleviating the dysfunction
Domain of function | Mod Pb | High Pb | ||
---|---|---|---|---|
Pb effect? | Succ. benefit? | Pb effect? | Succ. benefit? | |
Impaired learning ability | Yes | Yes | Yes | No |
Impaired regulation of arousal and/or negative emotion | No | NA | Yes | Yes |
Greater disruption following an error | ||||
Attentional dysfunction | ||||
Sustained attention/error reactivity | No | NA | Yes | Yes |
Lapses in attention | No | NA | Yes | Intermediate |
Impaired inhibitory control | No | NA | Yes | No |
Impulsivity |
Data from Stangle et al. [20]. [Reproduced with permission from Environmental Health Perspectives]
Pb effect? denotes whether a statistically significant effect of lead was detected, Succ. benefit? indicates whether succimer was efficacious at alleviating the lead induced dysfunction, NA not applicable