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Plot of specific activities (▪) of the 13 EB DHFR hybrids against crossover position. The total number of identified clashes (▵) [i.e., log(1 + number of clashes)] for each one of these hybrids is also shown. Note that the 0 and 159 crossover positions correspond to the parental B. subtilis and E. coli DHFR sequences, respectively. The specific activity and number of clashes for hybrid 62 are shown separately.
