Table 2. Positions, residue pairs, and nature of clashes in the hybrids.

Hybrid	Residue positions	Residue pair, parent 1	Residue pair, parent 2	Residue pair, hybrid	Nature of clash*
EB	17/63	ES	DT	ET	Steric
EB	30/97	WG	YA	WA	Steric/hyd
EB	36/135	LS	SL	LL	Steric/hyd
EB	47/149	WH	FY	WY	Steric/hyd
EB	62/63	LS	VT	LT	Steric
EB	62/69	LD	VE	LE	Steric
EB	62/78	LV	VL	LL	Steric
EB	62/99	LV	VL	LL	Steric
EB	62/104	LL	VF	LF	Steric
EB	80/127	ED	DE	EE	Steric
EB	80/156	EL	DY	EY	Steric
EB	98/146	RQ	QK	RK	Chg/steric/hyd
EB	127/129	DE	ED	DD	Cavity
EB	129/156	EL	DY	EY	Steric
BE	17/63	DT	ES	DS	Cavity
BE	36/135	SL	LS	SS	Cavity/hyd
BE	80/127	DE	ED	DD	Cavity
BE	92/103	FL	MF	FF	Hyd
BE	98/146	QK	RQ	QQ	Chg/steric/hyd
BE	127/129	ED	DE	EL	Steric

^*Clashes formed may be caused by departure from volume (steric hindrance-steric or cavity formation), charge (chg), or hydrophobicity (hyd) values observed in the protein family.