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. 2004 Mar 12;101(12):4158–4163. doi: 10.1073/pnas.0400699101

Fig. 5.

Fig. 5.

Sdc1–/– glands have reduced mammary gland complexity and SP cells. (A) Carmine-stained whole-mount preparations of mammary glands from 4- and 10-week-old control and Sdc1–/– mice are shown. The arrows indicate a typical terminal end bud (TEB) and end bud (EB) structures. (B) The results of morphometric analysis of the average number of TEBs and EBs per mammary gland of 4-week-old Sdc1+/+ and Sdc1–/– mice are shown. The number of TEBs is reduced by 47% (P = 4 × 10–5; 2-tailed Wilcoxon rank test). (C) The number of branches per gland of virgin 10-week-old Sdc1–/– mice was reduced by 43% (P = 0.01). (D) The relative fraction of SP cells was determined from three independent sorts of different MEC preparations from 6- to 7-month-old BALB/c Sdc1+/+ (30) and Sdc1–/– (25) mice. Younger mice (4–5 months old) or C57BL6 Sdc1–/– mice gave the same result.