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. 2013 Dec 2;8(12):e81679. doi: 10.1371/journal.pone.0081679

Table 3. Receptor dynamic parameters of methylprednisolone.

Parameter (units) Definition Value CV%
Inline graphic (fmol/g/h) Synthesis rate constant for GR mRNA 0.416 f/2.90g fixed
Inline graphic (fmol/mg protein) DRn required for 50% inhibition of GR mRNA production 15.6 f/26.2g/0.911h fixed
Inline graphic (h−1) Degradation rate constant for GR mRNA 0.427 f/0.139h 14.9 b
kon (nM−1·h−1) Association rate constant 0.016f/0.0033g/0.0027h fixed
kre (h−1) DRn loss rate constant 1.31 f/0.57g/0.618h fixed
Rf Recycling factor 0.93 f/0.49 g/0.72h fixed
kT (h−1) Translocation rate constant 58.2 f,h/0.63g fixed
Inline graphic (fmol/mg protein/fmol mRNA/g/h) Synthesis rate constant for GR 0.00196 f/0.777h fixed
Inline graphic (h−1) Degradation rate constant for GR 0.05 f,g/0.035h fixed
R(0) (fmol/mg protein) GR baseline: white adipose liver skeletal muscle 77.7f 420c,g/540.7b,d,g/328.7e,g 65.3h 13.3b
GRm(0) i (mol/ng RNA) GR mRNA baseline: white adipose 2050a,f/2200b-e,f fixed
GRm(0) (fmol/g) GR mRNA baseline: liver skeletal muscle 18.6c,g/25.8b-d,g/3.65e,g 2.99h fixed
a

IM injection control; b IM 50 mg injection; c IV 10 mg/kg injection; d IV 50 mg/kg injection;

e

IV infusion; f White adipose tissue; g Liver; h Skeletal muscle; i Different normalization for adipose tissue than for liver and skeletal muscle requires different units.