Table 4. Pharmacodynamic parameters for leptin dynamics and food intake.
| Parameter (units) | Definition | Value | CV% |
| Leptin dynamics | |||
 (h−1) |
Leptin mRNA loss rate constant | 0.0427 | 18.3 |
 (nM−1) |
Stimulation of leptin mRNA production | 0.0989 | 19.4 |
 (h−1) |
Leptin loss rate constant | 4.952 | 244.5 |
| Lepm(0) (mol/ng) | Baseline leptin mRNA concentration | 135600 a/155100 b/170000 c-h | 3.23a/4.88 b/fixed c-h |
| Lep(0) (pg/mL) | Baseline leptin concentration in plasma | 23650 a/25000 b/5170c-h | 3.21a/fixedb-h |
| Food intake | |||
| kin_Food0 (kcal/day−2) | Initial food input rate | 171 | Fixed |
| kin_FoodSS (kcal/day−2) | Steady-state food input rate | 147 | Fixed |
| Foodmax(kcal/day) | Maximal food intake | 57.9 | 9.35 |
 (pg/mL) |
Inhibition constant of leptin on kin_Food | 11550 | 22.4 |
| kFB (day−1) | Transduction rate constant | 0.0426 | 67.4 |
| kd (day−1) | Loss rate constant for food input | 1.21 | Fixed |
| Food 0 (kcal/day) | Food intake at start of study | 91.7c/80.3d/88.1e/88.5f/94.9g/88.6h (fixed) | Fixed |
a
IM injection control; b IM 50 mg injection; cSaline infusion; d 0.03 mg/kg/h; e 0.1 mg/kg/h; f 0.2 mg/kg/h; g0.3 mg/kg/h; h0.4 mg/kg/h.