Table 2.

Efficacy end-points

Assessment	Type of assessment	Criteria
Owner assessments
Pruritus (Primary endpoint)	Pruritus VAS	0 = “my dog is not itchy: no scratching, chewing, rubbing or licking observed”
		100 = “my dog is extremely itchy: scratching, chewing, rubbing or licking constantly”
		Individual pruritus observations on VAS at any time were expressed as a percentage:
		VAS_P = 100% × VAS length / total length of scale[13]
Overall assessment of clinical response	Score	[0] Poor: My dog’s dermatological condition has deteriorated or not changed compared to before treatment.
		[1] Moderate: My dog’s dermatological condition has only slightly improved compared to before treatment.
		[2] Good: My dog’s dermatological condition has clearly improved compared to before treatment.
		[3] Excellent: My dog’s dermatological condition has completely recovered as compared to before treatment.
Clinical assessments
Overall assessment of clinical response	Score	[0] Poor: worsening or no change of the clinical signs of the atopic dermatitis as compared to initial examination.
		[1] Moderate: slight amelioration of the clinical signs of the atopic dermatitis as compared to initial examination.
		[2] Good: clear amelioration of the clinical signs of the atopic dermatitis as compared to initial examination.
		[3] Excellent: Clinical signs of the atopic dermatitis observed during the first examination have completely disappeareds.
CADESI-03	Score	Completion of validated template grading erythema, lichenification, excoriations, alopecia and the sum score for all four lesions at 62 body sites (grades, none: 0; 1: mild; 2, 3: moderate; 4, 5: severe) [13].