Table 6.
Clinical signs reported and number of dogs affected per treatment group
| Clinical sign* | Cyclosporine A1(n = 25) | Cyclosporine A and prednisolone1(n = 23) | p-value |
|---|---|---|---|
| Digestive tract disorders |
20 (14) |
12 (8) |
0.1810 |
| Abdominal pain |
1 |
0 |
0.3589 |
| Digestive tract hypermotility |
0 |
1 |
0.3169 |
| Flatulence |
1 |
1 |
0.9762 |
| Diarrhea |
5 (5) |
7 (6) |
0.5815 |
| Stomatitis |
0 |
1 |
0.3169 |
| Vomiting |
13 (10) |
2 (2) |
0.0116 |
| Renal and urinary disorders |
4 (3) |
7 (5) |
0.3726 |
| Cystitis |
0 |
2 (2) |
0.1441 |
| Polyuria |
1 |
2 (2) |
0.5223 |
| Uremia |
0 |
1 |
0.3169 |
| Urinary incontinence |
1 |
0 |
0.3589 |
| Urine abnormalities |
2 (2) |
2 (2) |
0.9485 |
| Skin and appendages disorders |
10 (8) |
3 (3) |
0.1080 |
| Bacterial skin infection |
1 |
1 |
0.9762 |
| Dermatitis |
0 |
1 |
0.3169 |
| Erosion |
0 |
1 |
0.3169 |
| Fungal skin infection |
1 |
0 |
0.3589 |
| Papilloma |
1 |
0 |
0.3589 |
| Pruritus |
1 |
0 |
0.3589 |
| Pyoderma |
6 |
0 |
0.0264 |
| Systemic disorders |
2 (2) |
13 (8) |
0.0190 |
| Abnormal test result |
1 |
3 (3) |
0.2717 |
| Anorexia |
0 |
1 |
0.3169 |
| Lethargy |
0 |
4 (4) |
0.0329 |
| Polydipsia |
1 |
4 (4) |
0.1384 |
| Pyrexia |
0 |
1 |
0.3169 |
| Others |
|
|
|
| Hyperactivity |
1 |
0 |
0.3589 |
| Tachypnea |
1 |
1 |
0.9762 |
| Musculoskeletal disorder |
1 |
0 |
0.3589 |
| Acid–base disorder |
0 |
1 |
0.3169 |
| Conjunctivitis |
2 (2) |
1 |
0.6226 |
| Otitis externa | 2 (2) | 0 | 0.1798 |
*Several AEs had more than one clinical sign; total number of clinical signs reported: 81.
1The numbers in parentheses indicate the number of dogs showing the corresponding clinical sign. Dogs may have had more than one AE.