Table 2.
Predicted molecular parameters of the synthesized compounds
| Compound code | CLogP | Molecular weight | Number of HBA | Number of HBD | Solubility | Drug likeness | Drug score |
|---|---|---|---|---|---|---|---|
| 4a |
1.10 |
284 |
5 |
1 |
−2.45 |
2.29 |
0.7 |
| 4b |
1.00 |
314 |
6 |
1 |
−2.47 |
2.67 |
0.34 |
| 4c |
1.42 |
298 |
5 |
1 |
−2.79 |
2.54 |
0.42 |
| 4d |
1.72 |
318 |
5 |
1 |
−3.19 |
4.71 |
0.69 |
| 4e |
1.00 |
314 |
6 |
1 |
−2.47 |
3.65 |
0.43 |
| 4f |
1.42 |
298 |
5 |
1 |
−2.79 |
3.56 |
0.71 |
| 4g |
1.72 |
318 |
5 |
1 |
−3.19 |
3.93 |
0.69 |
| 4h |
1.00 |
314 |
6 |
1 |
−2.47 |
4.05 |
0.72 |
| 4i |
1.42 |
298 |
5 |
1 |
−2.79 |
4.07 |
0.71 |
| 4j |
1.72 |
318 |
5 |
1 |
−3.19 |
4.17 |
0.55 |
| 4k |
0.97 |
329 |
8 |
1 |
−2.91 |
−11.4 |
0.28 |
| 4l |
0.97 |
329 |
8 |
1 |
−2.91 |
−1.34 |
0.27 |
| 4m |
0.97 |
329 |
8 |
1 |
−2.91 |
−3.08 |
0.22 |
| 4n |
1.74 |
312 |
5 |
1 |
−3.14 |
0.76 |
0.47 |
| 4o |
1.74 |
312 |
5 |
1 |
−3.14 |
−0.22 |
0.32 |
| 4p | 2.03 | 332 | 5 | 1 | −3.53 | 3.93 | 0.66 |