Skip to main content
. 2004 Mar 15;101(12):4234–4239. doi: 10.1073/pnas.0400658101

Fig. 1.

Fig. 1.

Methionine, AdoMet, and AdoHcy metabolism. AdoMet, S-adenosylmethionine; AdoHcy, S-adenosylhomocysteine; THF, tetrahydrofolate; 5-MTHF, 5-methyltetrahydrofolate; AMP, adenosine monophosphate; MAT, methionine adenosyltransferase (E.C.2.5.1.6); GNMT, glycine N-methyltransferase (E.C.2.1.1.20); MTs, a variety of AdoMet-dependent methyltransferases; SAHH, AdoHcy hydrolase (E.C.3.3.1.1); CBS, cystathionine β-synthase (E.C.4.2.1.22); MS, methionine synthase (5-MTHF-homocysteine methyltransferase) (E.C.2.1.1.13); BHMT, betaine-homocysteine methyltransferase (E.C.2.1.1.5). The numbers represent the following: 1, sarcosine dehydrogenase (E.C.1.5.99.1); 2, N,N-dimethylglycine dehydrogenase (E.C.1.5.99.2); 3, phospholipase D (E.C.3.1.4.4); 4, choline dehydrogenase (E.C.1.1.99.1); 5, betaine aldehyde dehydrogenase (E.C.1.2.1.8); 6, methylenetetrahydrofolate reductase (MTHFR) (E.C.1.5.1.20); 7, γ-cystathionase (E.C.4.4.1.1); 8, glutamate–cysteine ligase (E.C.6.3.2.2); 9, glutathione synthase (E.C.6.3.2.3); 10, adenosine kinase (E.C.2.7.1.20); 11, adenosine deaminase (E.C.3.5.4.4); 12, AdoMet decarboxylase (E.C.4.1.1.50); 13, spermidine (spermine) synthase (E.C.2.5.1.16 and E.C.2.5.1.22); 14, methionine transamination pathway; and 15, phosphatidylethanolamine methyltransferase (PEMT) (E.C.2.1.1.17).