Table 2.
Referenced pathways enriched in the epithelial-mesenchymal transition-related gene clusters (EMT-GCs)
| GC | Pathway name | Enrichment | p-value |
|---|---|---|---|
| 16 |
Pathways in cancer |
4.618 |
0.00000627 |
| 16 |
Direct p53 effectors |
8.279 |
0.00000023 |
| 16 |
p53 signaling pathway |
7.100 |
0.09600000 |
| 16 |
Focal adhesion |
5.298 |
0.00013609 |
| 16 |
ECM-receptor interaction |
6.963 |
0.01242671 |
| 16 |
Cytokines and inflammatory response |
18.189 |
0.00875280 |
| 16 |
Interleukin-1 processing |
54.274 |
0.01740033 |
| 16 |
T cell receptor signaling pathway |
8.320 |
0.00000663 |
| 16 |
TNF-alpha/NF-kB signaling pathway |
4.280 |
0.03567735 |
| 16 |
CD40/CD40L signaling |
13.097 |
0.04278382 |
| 16 |
MAPK signaling pathway |
3.493 |
0.09603616 |
| 19 |
Pathways in cancer |
5.303 |
0.00000226 |
| 19 |
Focal adhesion |
6.245 |
0.00003282 |
| 19 |
E-cad sig in the nasc adherens junction |
24.776 |
0.00000267 |
| 19 |
Regulation of actin cytoskeleton |
6.012 |
0.00571942 |
| 19 |
Adherens junction |
13.011 |
0.00000273 |
| 19 |
Junction |
14.070 |
0.00496435 |
| 19 |
Canonical NF-kappaB pathway |
20.435 |
0.00422071 |
| 19 |
MAPK signaling pathway |
4.918 |
0.08357500 |
| 19 |
Leukocyte transendothelial migration |
8.442 |
0.00006173 |
| 19 |
T cell receptor signaling pathway |
8.321 |
0.00000663 |
| 19 | TGF-beta receptor signaling | 15.678 | 0.00001359 |
Pathways significantly enriched in GC16 and GC19. Only pathways directly referenced in the manuscript are shown. Pathways have been sourced from the NCBI Biosystems. Enrichment is the fold-change relative to the background frequency of a pathway annotation. P values are calculated by Fisher’s Exact Test and are false discovery rate (FDR) corrected.