Table 3.
Association of the APOAI rs670 (g.-75G > A) and the rs5069 (g. + 83C > T) polymorphisms and lipid profiles
| SNP | W/W | W/M | M/M | p | |||
|---|---|---|---|---|---|---|---|
| |
n |
|
n |
|
n |
|
|
|
SNPs relation with LDL |
|
|
|
|
|
|
|
|
rs670 |
344 |
2.99 ± 0.04 |
164 |
3.17 ± 0.06 |
21 |
3.03 ± 0.14 |
0.02 |
|
rs5069 |
491 |
3.07 ± 0.03 |
37 |
3.02 ± 0.14 |
1 |
3.00 |
0.59 |
|
SNPs relation with TC |
|
|
|
|
|
|
|
|
rs670 |
358 |
4.58 ± 0.04 |
170 |
4.75 ± 0.07 |
21 |
4.64 ± 0.19 |
0.03 |
|
rs5069 |
511 |
4.64 ± 0.04 |
37 |
4.60 ± 0.16 |
1 |
5.12 |
0.78 |
|
SNP relation with HDL |
|
|
|
|
|
|
|
|
rs670 |
344 |
1.18 ± 0.01 |
164 |
1.15 ± 0.02 |
21 |
1.28 ± 0.1 |
0.22 |
|
rs5069 |
491 |
1.18 ± 0.01 |
37 |
1.15 ± 0.04 |
1 |
1.02 |
0.79 |
|
SNP relation with TG |
|
|
|
|
|
|
|
|
rs670 |
358 |
0.74 |
170 |
0.72 |
21 |
0.68 |
0.93 |
| |
|
(0.49–1.21) |
|
(0.48–1.14) |
|
(0.40–0.95) |
|
|
rs5069 |
511 |
0.72 |
37 |
0.78 |
1 |
2.35 |
0.83 |
| (0.48–1.18 | (0.53–1.15) |
W/W, homozygous for common allele; W/M heterozygous for minor allele; M/M, homozygous for minor allele. The lipid level values are represented as mmol/L. Data shown as means ± SEM or for the lipid levels except for TG where the median and inter-quartile range is represented. p values were derived from multiple linear regressions with adjustment for sex, BMI and age assuming an additive genetic model. Significant values (p < 0.05) are shown in bold.