Figure 2.

miR-24 transgenic mice displayed severe defects in hair follicle morphogenesis. (a) Schematic representation of transgene vector cassette for Tg;K5::miR-24. (b and c) Gross morphology of K5::miR-24 transgenic mice at 10 days post birth. The arrows in c indicate spots where hair coat is absent. (e) Histogram quantification of hair follicle density per square centimeter in transgenic and wt. (d, f and g) Hematoxylin–eosin staining of back skin showing abnormal hair follicle morphology in P3 transgenic mice. Black arrows in D indicate a hair follicle that fails to penetrate in dermal tissue. White arrows indicate cyst-like hair follicles. Bars indicate the following: d, 200 μm; f, 50 μm; g, 200 and 50 μm