Table 4.

Application of CHERG Rules for selection of point estimate for sepsis mortality for inclusion to LiST model [7]

Outcome measure	Studies	Total Events	Effect size	GRADE quality of pooled estimate	Application of standard rules
Sepsis specific neonatal mortality	(n=1)	Not reported	31 % reduction, statistically non-significant (RR=0.69, 95 % CI 0.40-1.18)	Low	Effect size for sepsis specific mortality was not used for inclusion in LiST model as results were not statistically significant and overall quality grade was “low”
All cause neonatal mortality	(n=3)	838	23% reduction, Statistically significant (RR=0.77, 95 % CI 0.63 - 0.94)	Moderate → Low	Effect size for all-cause mortality was used for inclusion to LiST model. This was based on rule 1 that says that if there is no evidence for cause specific mortality and there is evidence for all-cause mortality, use the effect size for all-cause and down grade quality grade by one.