Table 1.
Association between the risk of DR and the combination of the ALDH2 genotypes and the serum GGT levels
| GGT levels† | ALDH2 genotype | n | HR‡ (95% CI) | P-value | HR‡ (95% CI) | P-value |
|---|---|---|---|---|---|---|
| Low |
*1/*1 genotype |
58 |
1 |
- |
- |
- |
| |
*2 allele carrier |
59 |
1.60 (0.77 - 4.09) |
0.25 |
- |
- |
| High |
*1/*1 genotype |
85 |
1.15 (0.53 - 2.49) |
0.73 |
1 |
- |
| *2 allele carrier | 32 | 2.63 (1.12-6.18) | 0.03 | 2.45 (1.10-5.48) | 0.03 |
†GGT was dichotomized by the near-median 37 IU/L for the males and 26 IU/L for the females.
‡Adjusted by gender, BMI, duration of diabetes, HbA1c and systolic BP.
DR, diabetic retinopathy; ALDH2, aldehyde dehydrogenase 2; GGT, γ-glutamyltransferase; HR, hazard ratio; CI, confidence interval; BMI, body mass index; HbA1c, hemoglobin A1c; BP, blood pressure.