Table 4.
Genotype frequencies of four polymorphisms in ONFH patients (total, idiopathic and secondary) and controls
| Genotype | Controls N=100 |
Patients |
||
|---|---|---|---|---|
| Total N=68 | Idiopathic n=45 | Secondary n=23 | ||
| Factor V Leiden | ||||
| GA |
3(3%) |
3(4,41%) |
3(6,67%) |
0 |
| GG |
97(97%) |
65(95,59%) |
42(93,33%) |
23(100%) |
| Prothrombin | ||||
| GA |
2(2%) |
1(1,47%) |
0 |
1(4,35%) |
| GG |
98(98%) |
67(98,53%) |
45(100%) |
22(95,65%) |
| MTHFR | ||||
| TT |
7(7%) |
4(5,88%) |
4(8,89%) |
0 |
| CT |
42(42%) |
35(51,47%) |
23(51,11%) |
12(52,17%) |
| CC |
51(51%) |
29(42,65%) |
18(40%) |
11(47,83%) |
| TPA | ||||
| DD |
18(18%) |
13(19,12%) |
11(24,44%)a |
2(8,7%) |
| ID |
37(37%) |
38(55,88%)b |
24(53,33%)c |
14(60,87%) |
| II | 45(45%) | 17(25%) | 10(22,22%) | 7(30,43%) |
a p=0,023; odds ratio (OR) 2,75; 95% confidence intervals (CIs) 0,99-7,95.
bp=0,004 OR 2,71; 95% CIs 1,32-5,57.
cp= 0,01; OR 2,91; 95% CIs 1,24-6,87.