Figure 2.

VprBP structural motifs and interacting proteins. The 1507 amino acid human VprBP isoform encoded by transcript variant ENST00000563997 in the Ensembl database (release 71) [29] is shown with the domain features for this isoform as described in the database or in the text. VprBP-interacting proteins are identified below the diagram; those for which the binding site has been mapped are shown below the region mediating the association. Proteins targeted for VprBP-dependent ubiquitination are boxed. The region removed after Cre-mediated deletion of a conditional allele [22], and the location of a DNA-PK-dependent phosphorylation site [30] are also indicated.