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. 2013 Dec 3;3:294. doi: 10.3389/fonc.2013.00294

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Copyright © 2013 Lozano, Casares and Lasarte.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanism by which FOXP3 influences the expression of NFAT-dependent genes: (i) by competing with NFAT for binding to DNA (77–79) (ii) by sequestering NFAT away from DNA (60) or by sequestering other NFAT partners, such as AP-1 (52) and (iii) by forming a FOXP3:NFAT cooperative complex (46).