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. 2013 Dec 3;3:294. doi: 10.3389/fonc.2013.00294

Figure 2.

Figure 2

Schematic representation of some of the FOXP3 partners, their site of interactions and functions. The N-terminal domain of FOXP3 can interact with c-Rel (nuclear factor κB transcription factor c-Rel), RORγt (Retinoic acid receptor-related orphan receptor gamma t), RORα (Retinoid-related orphan receptor alpha), Eos (Ikaros family zinc finger 4, IKZF4), TIP60 (histone acetyltransferase TIP60), HDAC7 (histone deacetylase 7), FIK (FOXP3-interacting KRAB domain containing protein), c-Jun (transcription factor c-Jun), STAT3 (Signal transducer and activator of transcription 3), IRF4 (interferon regulatory factor 4). The Leucine zipper domain can interact with FOXP3, FOXP1, or H1.5 (Histone H1.5). The FKH domain can interact with FOXP3, NFAT (nuclear factor of activated T cells), the DNA or HIF-1α (Hypoxia-inducible factor 1α). Dots in red represent sites of phosphorylation and dots in blue represents sites of acetylation. NLS, nuclear localization sequences.