Table 1.

Median, first (1.Qu) and third (3.Qu) quartile concentration (ng/mL) for each cytokine, for OKT3/5C3-stimulated blood: one control and three antidepressants at 1- and at 2-fold maximum therapeutic concentration. N = 15 for all comparisons. Control refers to OKT3/5C3-stimulated blood without antidepressant. * = significant difference between OKT3/5C3-stimulated values with and without drug at specified concentration (uncorrected p < 0.05, non-parametric Wilcoxon test).

	Concentration	1-fold				2-fold
		Median	1.Qu	3.Qu		Median	1.Qu	3.Qu
IL-1β	Control	1.6	0.1	4.3
	Citalopram	5.0*	0.8	37.7		7.0*	0.6	37.3
	Escitalopram	1.3	0.0	4.5		1.2	0.0	3.6
	Mirtazapine	3.1*	0.0	37.7		5.0*	0.0	45.2
IL-2	Control	0.0	0.0	0.0
	Citalopram	0.0	0.0	2.4		0.0	0.0	1.9
	Escitalopram	0.0	0.0	1.0		0.0	0.0	1.2
	Mirtazapine	0.0	0.0	0.0		0.0	0.0	0.0
IL-4	Control	0.1	0.0	7.2
	Citalopram	1.5	0.0	10.8		2.7	0.0	14.0
	Escitalopram	0.6	0.0	8.5		0.6	0.0	6.5
	Mirtazapine	0.8	0.0	4.0		1.9	0.0	9.5
IL-6	Control	2.8	0.9	82.4
	Citalopram	49.8*	2.4	428.0		58.1*	4.6	405.6
	Escitalopram	6.1	0.3	111.7		3.7	0.7	62.6
	Mirtazapin	5.6	0.4	76.2		24.6	0.1	470.0
IL-17	Control	3.4	0.1	9.4
	Citalopram	10.6	0.0	15.5		8.2	0.6	14.2
	Escitalopram	3.2	0.0	7.9		1.3*	0.1	3.1
	Mirtazapine	4.7	0.0	8.3		9.0	0.0	10.4
IL-22	Control	0.0	0.0	188.9
	Citalopram	42.0*	0.0	366.1		96.1*	0.0	575.0
	Escitalopram	0.0	0.0	55.1		0.0	0.0	187.3
	Mirtazapine	24.6	0.0	284.2		69.6*	0.0	403.4
TNF-α	Control	3.8	0.0	298.0
	Citalopram	38.3	0.0	347.7		153.3*	0.7	400.9
	Escitalopram	4.1	0.0	32.7		2.8	0.0	167.4
	Mirtazapine	41.9	0.0	365.6		205.3*	0.0	659.2